Upregulation of GRP78 is accompanied by decreased antioxidant response and mitophagy promotion in streptozotocin-induced type 1 diabetes in rats - original data

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dc.contributorAdamczyk-Grochala, Jagoda
dc.contributor.authorKaniuka, Olena
dc.contributor.authorDeręgowska, Anna
dc.contributor.authorBandura, Yurii
dc.contributor.authorSabadashka, Mariya
dc.contributor.authorChala, Dariya
dc.contributor.authorKulachkovskyi, Olexandr
dc.contributor.authorKubis, Hubert
dc.contributor.authorAdamczyk-Grochala, Jagoda
dc.contributor.authorSybirna, Nataliia
dc.date.accessioned2024-11-12T09:59:07Z
dc.date.available2024-11-12T09:59:07Z
dc.date.issued2024-09-25
dc.descriptionRaw data in a xlsx file: Original data used to generate the presentation of results in the figure 1-4.
dc.description.abstractEndoplasmic reticulum stress, oxidative stress, and mitochondrial dysfunction are interconnected processes involved in the pathogenesis of diabetes mellitus (DM). In the present study, we demonstrate a distinct unfolded protein response (UPR) signaling pathways in two mammalian models of DM: β-TC-6 cell line and streptozotocin induced type 1 diabetes model in rats. However, a feature common to both systems was the upregulation of the GRP78 protein. Moreover, in vivo studies showed the disruption of the antioxidant system and an escalation of mitophagy against the background of a depletion of the level of ATP in pancreatic cells. In conclusion, we suggest that glucotoxic conditions induced GRP78 upregulation, and next cause depletion of the antioxidant pool and disruption of the functioning of antioxidant defense enzymes and in consequence promote mitophagy in pancreatic cells. Therefore, GRP78 may be considered as a potential therapeutic factor in patients with diabetes.
dc.description.sponsorshipThis work was supported by the National Science Centre of Poland, Miniatura 5, Grant number: 2021/05/X/NZ3/01000.
dc.identifier.doi10.1016/j.bbadis.2024.167531
dc.identifier.urihttps://rdb.ur.edu.pl/handle/item/52
dc.language.isoen
dc.publisherBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
dc.subjectDiabetes mellitus
dc.subjectEndoplasmic reticulum stress
dc.subjectMitophagy
dc.subjectOxidative stress
dc.subjectGRP78
dc.titleUpregulation of GRP78 is accompanied by decreased antioxidant response and mitophagy promotion in streptozotocin-induced type 1 diabetes in rats - original data
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