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Item type: Item , Dataset used in research paper entitled "The thiocarbonyl analog of chrysin induces apoptosis and oxidative stress-mediated unfolded protein response in breast cancer cells "(Elsevier, 2026-11-15) Witkowski, Wojciech; Deręgowska, Anna; Kapavarapu, Ravikumar; Stec, Paulina; Pieszko, Weronika; Kołodziej, Olga; Żebrowski, Michał; Boruc, Martyna; Łętowski, Piotr; Łukaszyk, Michał; Wnuk, Maciej; Litwinienko, Grzegorz; Lewińska, AnnaNatural flavones such as chrysin and baicalein were characterized by a wide range of biological activities including, among others, antioxidant and anticancer action. Nevertheless, their use in biomedical applications is restricted due to limited bioavailability. In the present study, C4 thionation-based approach was considered to produce thiochrysin and thiobaicalein with improved anticancer activity. The thiocarbonyl analogs were tested against breast cancer cells with different receptor status (MCF-7 ER-positive, MDA-MB-231 TNBC, and SK-BR-3 HER2-positive) along with the corresponding normal cells MCF-10F. Thiochrysin, when used at the concentration of 1 μM, sensitized MCF-7 and SK-BR-3 cells to apoptotic cell death compared to the action of parent flavone chrysin that was associated with elevated production of superoxide. Thiochrysin-mediated oxidative stress in MCF-7 cells resulted in the activation of unfolded protein response (UPR) as judged by increased phosphorylated status of IRE1, elevated levels of ATF6 and ER-associated chaperone GRP78. Cytotoxic potential of thiochrysin was also documented using 3D breast cancer cell-based spheroid models. Thiochrysin was also active against doxorubicin-induced senescent and drug-resistant MCF-7 and SK-BR-3 cells. In contrast, anti-breast cancer action of thiobaicalein was less pronounced. In silico approaches such as molecular simulations and ADMET profiling were also used to predict thiochrysin action in in vivo situations. In conclusion, we postulate that C4 thionation may potentiate the anticancer action of selected flavones, here chrysin, based on oxidative stress-mediated apoptosis.Item type: Item , Zielony pierścień Rzeszowa. Uwarunkowania przestrzenne i wyzwania społeczne(2025-12) Gajdek, Agata; Ortyl, Bernadetta; Ćwik, AgataDynamiczny rozwój przestrzenny Rzeszowa, związany m.in. z sukcesywnym poszerzaniem granic administracyjnych miasta, doprowadził do włączenia rozległych terenów otwartych i rolniczych, stanowiących istotny element jego systemu przyrodniczego. Celem opracowania była ocena potencjału kształtowania zielonego pierścienia Rzeszowa oraz identyfikacja głównych uwarunkowań przestrzennych i społecznych ograniczających jego zachowanie. Analizie poddano rozmieszczenie terenów biologicznie czynnych, strukturę pokrycia terenu w granicach miasta i w jego bezpośrednim otoczeniu, a także relacje między istniejącym potencjałem przyrodniczym a kierunkami rozwoju przestrzennego. Rzeszów charakteryzuje się stosunkowo wysokim udziałem terenów biologicznie czynnych, szczególnie w strefach peryferyjnych i na obszarach przyłączonych do miasta w ostatnich dekadach. Ich rozmieszczenie i względna ciągłość wskazują na możliwość kształtowania pierścieniowego systemu terenów otwartych wokół zurbanizowanego rdzenia miasta. Potencjał ten jest jednak osłabiany przez niewielki udział lasów, postępującą presję inwestycyjną oraz fragmentację terenów rolniczych i innych powierzchni biologicznie czynnych. Dodatkowym wyzwaniem pozostaje społeczne przyzwolenie na zabudowę terenów rolnych, wzmacniające proces ich stopniowej urbanizacji. Analiza dokumentów planistycznych wskazuje ponadto na brak dostatecznie konsekwentnej ochrony ciągłości potencjalnego zielonego pierścienia. Wyniki podkreślają potrzebę traktowania terenów otwartych na obrzeżach Rzeszowa jako strategicznego elementu zielonej infrastruktury oraz ich trwałego uwzględnienia w polityce przestrzennej miasta.Item type: Item , Probing gluon GTMDs of the proton in deep inelastic diffractive dijet production at HERA(American Physical Society, 2024-09-20) Linek, Barbara; Łuszczak, Marta; Schäfer, Wolfgang; Szczurek, AntoniWe calculate several differential distributions for diffractive dijets production in ep→e′jet jet p in the perturbative QCD dipole approach using off diagonal unintegrated gluon distributions (generalized transverse momentum dependent distributions, GTMDs). Different models from the literature are used. We concentrate on the contribution from exclusive qqbar dijets. Results of our calculations are compared to H1 and ZEUS data, including specific experimental cuts in our calculations. In general, except for one GTMD, our results are below the HERA data. The considered mechanism is expected to gives a sizeable contribution to the ZEUS data, while it is negligible in the kinematics of the H1 measurement. This is in contrast to recent results from the literature where the normalization was adjusted to some selected distributions of the H1 collaboration and no agreement with other observables was checked. The ZEUS data provide stricter limitations on the GTMDs than the H1 data. We conclude, based on comparison to different observables, that the calculated cross sections are only a small fraction of the measured ones which contain probably also processes with pomeron remnant. Alternatively one could try to explain the experimental data by inclusion of qqbarg component of the photon wave function. We present also azimuthal correlations between the sum and the difference of dijet transverse momenta. The cuts on transverse momenta of jets generate corresponding azimuthal correlations that can be misidentified as due to elliptic gluon distributions.Item type: Item , Probing GPDs in Exclusive Electroproduction of Dijets Data(American Physical Society, 2026-06-08) Chall, Trambak Jyoti; Łuszczak, Marta; Schäfer, Wolfgang; Szczurek, AntoniWe summarize the formalism for calculating the exclusive dijet production in 𝑒𝑝 →𝑒′𝑗𝑗𝑝 in collinear QCD factorization, using generalized parton distributions as the soft hadronic input modeled in the double distribution approach. We include all leading-order contributions coming from light sea and valence quark exchanges, and gluon exchanges for both light quark-antiquark production and also the heavy 𝑐 \bar𝑐 final state. We present results for several differential distributions for the cross section evaluated over a broad region of phase space, covering a wide range of inelasticity and photon virtuality. The gluon and sea contributions exhibit similar shapes, whereas the valence contribution, though relatively small, shows a markedly different behavior. The latter becomes particularly noticeable at large 𝑥ℙ, a kinematic region not explored at HERA, but potentially accessible in future measurements at the Electron Ion Collider. This requires further feasibility studies. We also present the azimuthal angle modulation between the leptonic and the outgoing dijet planes for the general case, as well as for the ZEUS kinematic region where we see reasonable agreement with the data for diffractive deep inelastic scattering parameter 𝛽 ≳0.4.Item type: Item , Complete database of the oak regeneration census performed in 2022-2024 in abandoned agricultural land(2026-08) Bobiec, AndrzejComplete database of the oak regeneration census performed in 2022-2024 in abandoned agricultural land contains Excel spreadsheet including the cross-checked database of all records (oak seedlings/saplings) with their geographic coordinates. Besides basic biometric parameters (height, diameter of the root collar, diameter at breast hight, sread of crown), the table includes other qualitative traits. There is the box frame in the sheet with variables' definitions (in Polish) - sheet "DbRegAll-NCN". The second sheet "Delta-H" collects the data referring to the saplings' vertical growth rate.