Dataset used in research paper entitled "Evaluation of anticancer activity of urotropine surface modified iron oxide nanoparticles using a panel of forty breast cancer cell lines "

Simple item page
dc.contributorWnuk, Maciej
dc.contributor.authorAdamczyk-Grochala, Jagoda
dc.contributor.authorWnuk, Maciej
dc.contributor.authorOklejewicz, Bernadetta
dc.contributor.authorKlimczak, Katarzyna
dc.contributor.authorBłoniarz, Dominika
dc.contributor.authorDeręgowska, Anna
dc.contributor.authorRzeszutek, Iwona
dc.contributor.authorStec, Paulina
dc.contributor.authorCiuraszkiewicz, Agnieszka
dc.contributor.authorKądziołka-Gaweł, Mariola
dc.contributor.authorŁukowiec, Dariusz
dc.contributor.authorPiotrowski, Piotr
dc.contributor.authorLitwinienko, Grzegorz
dc.contributor.authorRadoń, Adrian
dc.contributor.authorLewińska, Anna
dc.date.accessioned2025-03-31T05:57:41Z
dc.date.available2025-03-31T05:57:41Z
dc.date.issued2025-02-28
dc.descriptionThe data presented in this study are available in the Supporting Information in https://www.tandfonline.com/doi/suppl/10.1080/17435390.2025.2450196 File 1: Additional original data used to generate the presentation of results in figure 1 and S1 File 2: Original data used to generate the presentation of results in figure 2-7, S2 - S35.
dc.description.abstractUrotropine, an antibacterial agent to treat urinary tract bacterial infections, can be also considered as a repurposed drug with formaldehyde-mediated anticancer activity. Recently, we have synthesized urotropine surface modified iron oxide nanoparticles (URO@Fe3O4 NPs) with improved colloidal stability and limited cytotoxicity against human fibroblasts. In the present study, we have investigated URO@Fe3O4 NP-mediated responses in a panel of forty phenotypically different breast cancer cell lines along with three non-cancerous corresponding cell lines. URO@Fe3O4 NPs promoted oxidative stress and FOXO3a-based antioxidant response in breast cancer cells. Elevated levels of GPX4 and decreased levels of ACSL4 in URO@Fe3O4 NP-treated breast cancer cells protected against ferroptotic cell death. On the contrary, URO@Fe3O4 NPs impaired the activity of PERK, a part of unfolded protein response (UPR), especially when the glucose supply was limited, that was accompanied by genetic instability, and apoptotic and/or necrotic cell death in breast cancer cells. In conclusion, this is the first comprehensive analysis of anticancer effects of URO@Fe3O4 NPs against a panel of forty breast cancer cell lines with different receptor status and in glucose replete and deplete conditions. We suggest that presented results might be helpful for designing new nano-based anti-breast cancer strategies.en
dc.description.sponsorshipThis work was supported by the National Science Centre (NCN, Poland) grant OPUS 22 No. 2021/43/B/NZ7/02129
dc.identifier.citationAdamczyk-Grochala J, Wnuk M, Oklejewicz B, Klimczak K, Błoniarz D, Deręgowska A, Rzeszutek I, Stec P, Ciuraszkiewicz A, Kądziołka-Gaweł M, Łukowiec D, Piotrowski P, Litwinienko G, Radoń A, Lewińska A. Evaluation of anticancer activity of urotropine surface modified iron oxide nanoparticles using a panel of forty breast cancer cell lines. Nanotoxicology. 2025 Feb;19(1):50-68. doi: 10.1080/17435390.2025.2450196.
dc.identifier.doihttps://doi.org/10.1080/17435390.2025.2450196
dc.identifier.urihttps://rdb.ur.edu.pl/handle/item/68
dc.language.isoen
dc.publisherTaylor & Francis
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPERK
dc.subjectUrotropine
dc.subjectapoptosis
dc.titleDataset used in research paper entitled "Evaluation of anticancer activity of urotropine surface modified iron oxide nanoparticles using a panel of forty breast cancer cell lines "
dc.typeraw dataset
Files
Original bundle
Now showing 1 - 1 of 1
Name:
dataset.rar
Size:
4.52 MB
Format:
Unknown data format
Download
Collections
Instytut Biotechnologii / Institute of Biotechnology