Kolegium Nauk Medycznych / College of Medical Sciences

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Browsing Kolegium Nauk Medycznych / College of Medical Sciences by Subject "low-grade inflammation"

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    Body composition, lifestyle and nutrients on adiponectin and resistin levels and AR index in obese individuals
    (2024) Polak-Szczybyło, Ewelina; Tabarkiewicz, Jacek
    Background: Low-grade inflammation resulting from processes occurring in the adipose tissue of obese people is a factor in the occurrence of numerous diseases. Current research focuses on ways to regulate immunological mechanisms in adipose tissue in order to minimize the consequences for the health. Methods: Body composition analysis using BIA was performed among 84 adults with obesity (BMI ≥ 30 kg/m2). Serum was collected to analyze the concentration of adiponectin (ApN) and resistin. The subjects additionally completed a food frequency questionnaire FFQ-6 and a three-days food diary. Adiponectin-resistin index (AR index) was calculated. Results: Re-sistin showed a positive correlation with BMI and subcutaneous adipose tissue content. AR index value was also positively associated with the amount of adipose tissue and body mass. Adi-ponectin level in the blood of the studied individuals decreased with the content of lean tissue. Adiponectin level also decreased with the amount of carbohydrates, e.g. starch, and glycemic load of the diet. Resistin decreased in patients who frequently consumed white pasta and red meat, while AR index was positively associated with the amount of white rice and SFA and MUFA fatty acids consumed and negatively with the frequent consumption of carbohydrates, including starch. Physical activity was negatively correlated with adiponectin levels and AR index. Con-clusion: Body composition significantly affected the AR index and concentration of resistin and adiponectin in the blood of the subjects. Dietary factors also had a significant effect.
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    Obesity and IL-21, IL-22, IL-23 in low-grade inflammation. Can they be manipulated by nutrition and stimulants?
    (2025) Polak-Szczybyło, Ewelina; Tabarkiewicz, Jacek
    Background: The IL-21, IL-22, and IL-23 are screened evaluated most often in patients with autoimmune or inflammatory diseases. There is a paucity of research focused on these cytokines in the obesity and its associated low-grade inflammation. Methods: The concentrations of IL-21, IL-22, and IL-23 Serum were analysed in serum samples from of obese 84 obese subjects were analysed for the concetrations of IL-21, IL-22, and IL-23. In addition, each respondent of them had to complete the nutrition questionnaire and diary. Body composition analysis was performed using the bioimpedance method. Results: The level of IL-23 was negatively correlated statistically associated with the BMI value. Alcohol consumption decreases the level of IL-21 and Tobacco smoking increases the level of IL-21 and IL-23. People who practice sports have higher IL-23 levels than people those who do not. practice sports. Dietary factors such as the amount and type of carbohydrates in diet, the glycaemic index, the frequency of consumption of complex carbohydrates (wholemeal pasta), fast-foods, cottage cheese, eggs and fish affect the mentioned interleukins. Also the level of retinol, niacyne, ryboflavine, omega-3 and beta-carotene in diet influence the level of tested cytokines. Conclusion: In obese individuals without autoimmune diseases, reduced levels of IL-23 occur. IL-21, 22 and 23 may be influenced by lifestyle factors, ege.g., addictions, physical activity, frequency of consumption of particular product groups, and the content of nutrients in the diet.