Kolegium Nauk Medycznych / College of Medical Sciences

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  • Item
    Body composition, lifestyle and nutrients on adiponectin and resistin levels and AR index in obese individuals
    (2024) Polak-Szczybyło, Ewelina; Tabarkiewicz, Jacek
    Background: Low-grade inflammation resulting from processes occurring in the adipose tissue of obese people is a factor in the occurrence of numerous diseases. Current research focuses on ways to regulate immunological mechanisms in adipose tissue in order to minimize the consequences for the health. Methods: Body composition analysis using BIA was performed among 84 adults with obesity (BMI ≥ 30 kg/m2). Serum was collected to analyze the concentration of adiponectin (ApN) and resistin. The subjects additionally completed a food frequency questionnaire FFQ-6 and a three-days food diary. Adiponectin-resistin index (AR index) was calculated. Results: Re-sistin showed a positive correlation with BMI and subcutaneous adipose tissue content. AR index value was also positively associated with the amount of adipose tissue and body mass. Adi-ponectin level in the blood of the studied individuals decreased with the content of lean tissue. Adiponectin level also decreased with the amount of carbohydrates, e.g. starch, and glycemic load of the diet. Resistin decreased in patients who frequently consumed white pasta and red meat, while AR index was positively associated with the amount of white rice and SFA and MUFA fatty acids consumed and negatively with the frequent consumption of carbohydrates, including starch. Physical activity was negatively correlated with adiponectin levels and AR index. Con-clusion: Body composition significantly affected the AR index and concentration of resistin and adiponectin in the blood of the subjects. Dietary factors also had a significant effect.
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    Change in patients’ psychophysical performance following lumbar discectomy relative to the postoperative rehabilitation programme
    (2019) Wolan-Nieroda, Andżelina; Sobański, Grzegorz; Guzik, Agnieszka; Maciejczak, Andrzej
    Abstract Background. The aim of this study was to assess the change in psychophysical performance of patients after lumbar discectomy in relation to the postoperative rehabilitation programme. Material and Methods. The study involved 60 participants randomly divided into two groups of 30 individuals. Both groups participated in a basic version of the rehabilitation programme, and individuals in the study group additionally received manual therapy. The evaluation was performed twice, before the start and after the completion of the 3-month rehabilitation programme. The tests were carried out to measure static balance, functional status using Oswestry Disability Index (ODI) and Roland-Morris Disability Questionnaire (RMDQ), lumbar spine range of motion using the original Schober’s test and the intensity of pain using the Visual Analogue Scale (VAS). Results. Both groups showed significant improvement in most of the psychophysical parameters assessed (study versus control p<0.01;p<0.05), except for the parameters of balance. In the study group, significant changes occurred in all parameters except X average, Area circular and average velocity in trials with eyes closed and left leg stance after rehabilitation (p<0.05). The findings showed significant differences in the reduced pain intensity on the VAS (p=0.0001), improved functional status in ODI and improved static balance (p<0.01), in favour of the study group. Conclusion. The protocol which additionally included manual therapy was found to be more effective than the basic programme. Its superiority was reflected by greater pain reduction, more visibly improved functional status as well as improved static balance.
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    Change in patients’ psychophysical performance following lumbar discectomy relative to the postoperative rehabilitation programme
    (2023) Wolan-Nieroda, Andżelina; Sobański, Grzegorz; Guzik, Agnieszka; Maciejczak, Andrzej
    Abstract Background: The aim of this study was to assess the change in psychophysical performance of patients after lumbar discectomy in relation to the postoperative rehabilitation programme. Material and Methods: The study involved 60 participants randomly divided into two groups of 30 individuals. Both groups participated in a basic version of the rehabilitation programme, and individuals in the study group additionally received manual therapy. The evaluation was performed twice, before the start and after the completion of the 3-month rehabilitation programme. The tests were carried out to measure static balance, functional status using Oswestry Disability Index (ODI) and Roland-Morris Disability Questionnaire (RMDQ), lumbar spine range of motion using the original Schober’s test and the intensity of pain using the Visual Analogue Scale (VAS). Results: Both groups showed significant improvement in most of the psychophysical parameters assessed (study versus control p<0.01;p<0.05), except for the parameters of balance. In the study group, significant changes occurred in all parameters except X average, Area circular and average velocity in trials with eyes closed and left leg stance after rehabilitation (p<0.05). The findings showed significant differences in the reduced pain intensity on the VAS (p=0.0001), improved functional status in ODI and improved static balance (p<0.01), in favour of the study group. Conclusion: The protocol which additionally included manual therapy was found to be more effective than the basic programme. Its superiority was reflected by greater pain reduction, more visibly improved functional status as well as improved static balance.
  • Item
    Change in patients’ psychophysical performance following lumbar discectomy relative to the postoperative rehabilitation programme
    (2019) Wolan-Nieroda, Andżelina; Sobański, Grzegorz; Guzik, Agnieszka; Maciejczak, Andrzej
    Abstract Background. The aim of this study was to assess the change in psychophysical performance of patients after lumbar discectomy in relation to the postoperative rehabilitation programme. Material and Methods. The study involved 60 participants randomly divided into two groups of 30 individuals. Both groups participated in a basic version of the rehabilitation programme, and individuals in the study group additionally received manual therapy. The evaluation was performed twice, before the start and after the completion of the 3-month rehabilitation programme. The tests were carried out to measure static balance, functional status using Oswestry Disability Index (ODI) and Roland-Morris Disability Questionnaire (RMDQ), lumbar spine range of motion using the original Schober’s test and the intensity of pain using the Visual Analogue Scale (VAS). Results. Both groups showed significant improvement in most of the psychophysical parameters assessed (study versus control p<0.01;p<0.05), except for the parameters of balance. In the study group, significant changes occurred in all parameters except X average, Area circular and average velocity in trials with eyes closed and left leg stance after rehabilitation (p<0.05). The findings showed significant differences in the reduced pain intensity on the VAS (p=0.0001), improved functional status in ODI and improved static balance (p<0.01), in favour of the study group. Conclusion. The protocol which additionally included manual therapy was found to be more effective than the basic programme. Its superiority was reflected by greater pain reduction, more visibly improved functional status as well as improved static balance.
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    Dataset used in research paper entitled "Plasma Circular-RNA 0005567 as a Potential Marker of Disease Activity in Rheumatoid Arthritis"
    (MDPI, 2023-12-28) Cieśla, Marek
    Circular RNAs (circRNAs) are noncoding molecules and are generated through back splicing. The 3′ and 5′ ends of the RNAs are covalently linked and form a loop structure, making it resistant to RNA exonucleases. Thus, circRNAs are biologically stable and may be considered as potential molecular markers of various diseases in tissues and biofluids. CircRNAs may regulate gene expression levels by acting as a microRNA sponge or by interacting with RNA binding proteins. The aim of the study was to find an association between plasma concentration of selected circRNAs and disease activity in patients with RA.
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    NGS Bladder cancer
    (2024-10-08) Cieśla, Marek
    The study group comprises 46 patients with urothelial bladder cancers referred for transurethral resection of the tumour. A molecular study on tumour-derived DNA was performed using next-generation sequencing. Somatic mutations were screened in 50 genes involved in cancerogenesis
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    Stworzenie i walidacja nowego wzoru do obliczania Podstawowej Przemiany Materii u dzieci i młodzieży aktywnych fizycznie - MINIATURA 5
    (2023) Łuszczki, Edyta
    Measurement or estimation of resting energy expenditure (REE) should be the first step in determining energy demand in physically active boys. The purpose of this study was to develop and validate new equations for resting energy expenditure in male children and adolescents practicing soccer. The cross-sectional studywas carried out among 184 boys in the derivation group and 148 boys in the validation group (mean age 13.20 ± 2.16 years and 13.24 ± 1.75 years, respectively). The calorimeter and device for assessing body composition by bioelectrical impedance analysis (BIA) were used. Model of multiple regression showed that REE can be predicted in this population with Eq. (1) (with height and weight data) or Eq. (2) (with age, height, and fat free mass data). Predictive Eq. (1) had an average error of 51 ± 199 kcal and predictive Eq. (2) − 39 ± 193 kcal. Cohen’s d coefficient was 0.2, which confirms the small difference. The bias was 4.7% and 3.9%, respectively. The accuracy was 61.2% in the population for predictive Eq. (1) and 66.2% for predictive Eq. (2). Therefore, the new equations developed and validated in this study are recommended for the estimation of REE in physically active boys, when the use of IC is not feasible or available.