Obesity and IL-21, IL-22, IL-23 in low-grade inflammation. Can they be manipulated by nutrition and stimulants?
Date
2025
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Abstract
Background: The IL-21, IL-22, and IL-23 are screened evaluated most often in patients with autoimmune or inflammatory diseases. There is a paucity of research focused on these cytokines in the obesity and its associated low-grade inflammation. Methods: The concentrations of IL-21, IL-22, and IL-23 Serum were analysed in serum samples from of obese 84 obese subjects were analysed for the concetrations of IL-21, IL-22, and IL-23. In addition, each respondent of them had to complete the nutrition questionnaire and diary. Body composition analysis was performed using the bioimpedance method. Results: The level of IL-23 was negatively correlated statistically associated with the BMI value. Alcohol consumption decreases the level of IL-21 and Tobacco smoking increases the level of IL-21 and IL-23. People who practice sports have higher IL-23 levels than people those who do not. practice sports. Dietary factors such as the amount and type of carbohydrates in diet, the glycaemic index, the frequency of consumption of complex carbohydrates (wholemeal pasta), fast-foods, cottage cheese, eggs and fish affect the mentioned interleukins. Also the level of retinol, niacyne, ryboflavine, omega-3 and beta-carotene in diet influence the level of tested cytokines. Conclusion: In obese individuals without autoimmune diseases, reduced levels of IL-23 occur. IL-21, 22 and 23 may be influenced by lifestyle factors, ege.g., addictions, physical activity, frequency of consumption of particular product groups, and the content of nutrients in the diet.
Description
The data concern the levels of interleukin 21, 22, 23 in the group of obese people and the results of the body composition analysis, the FFQ-6 questionnaire (frequency of consumption of food groups), the food diary and questions related to physical activity, diseases, dietary habits and personal details.
Keywords
low-grade inflammation, obesity, IL-21, IL-22, IL-23, adipokines, nutrients, diet
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CC0 1.0 Universal
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This research received no external funding.
Type
raw dataset