Surowe dane badawcze do artykułu "Virtually identical does not mean exactly identical: Discrepancy in energy metabolism between glucose and fructose fermentation influences the reproductive potential of yeast cells"

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dc.contributorMaślanka, Roman
dc.contributor.authorMaślanka, Roman
dc.contributor.authorBednarska, Sabina
dc.contributor.authorZadrąg-Tęcza, Renata
dc.date.accessioned2024-10-30T07:55:00Z
dc.date.available2024-10-30T07:55:00Z
dc.date.issued2024-05-03
dc.descriptionExcel file with raw data. Separate sheet for each experimental method used in studies or group of connected parameters (e.g., PPP parameters - determined parameters connected with pentose phosphate pathway). These raw data were used to prepare bar graphs, standard deviations, and violin plots. Metadata that allows the identification of specific samples and methods are included in the description of each sheet.
dc.description.abstractThe physiological efficiency of cells largely depends on the possibility of metabolic adaptations to changing conditions, especially on the availability of nutrients. Central carbon metabolism has an essential role in cellular function. In most cells is based on glucose, which is the primary energy source, provides the carbon skeleton for the biosynthesis of important cell macromolecules, and acts as a signalling molecule. The metabolic flux between pathways of carbon metabolism such as glycolysis, pentose phosphate pathway, and mitochondrial oxidative phosphorylation is dynamically adjusted by specific cellular economics responding to extracellular conditions and intracellular demands. Using Saccharomyces cerevisiae yeast cells and potentially similar fermentable carbon sources i.e. glucose and fructose we analyzed the parameters concerning the metabolic status of the cells and connected with them alteration in cell reproductive potential. Those parameters were related to the specific metabolic network: the hexose uptake - glycolysis and activity of the cAMP/PKA pathway - pentose phosphate pathway and biosynthetic capacities - the oxidative respiration and energy generation. The results showed that yeast cells growing in a fructose medium slightly increased metabolism redirection toward respiratory activity, which decreased pentose phosphate pathway activity and cellular biosynthetic capabilities. These differences between the fermentative metabolism of glucose and fructose, lead to long-term effects, manifested by changes in the maximum reproductive potential of cells.
dc.description.sponsorshipThis research was funded in whole by the Polish National Science Centre (Grant No.: 2021/05/X/NZ3/00162).
dc.identifier.citationMaslanka R, Bednarska S, Zadrag-Tecza R. Virtually identical does not mean exactly identical: Discrepancy in energy metabolism between glucose and fructose fermentation influences the reproductive potential of yeast cells. Arch Biochem Biophys. 2024 Jun;756:110021.
dc.identifier.doidoi: 10.1016/j.abb.2024.110021.
dc.identifier.urihttps://rdb.ur.edu.pl/handle/item/48
dc.language.isoen
dc.publisherArchives of Biochemistry and Biophysics
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectfructose vs glucose
dc.subjectreproductive potential
dc.subjectcellular metabolism
dc.subjectmitochondrial respiration
dc.subjectcarbon catabolite repression
dc.subjecthexokinase
dc.titleSurowe dane badawcze do artykułu "Virtually identical does not mean exactly identical: Discrepancy in energy metabolism between glucose and fructose fermentation influences the reproductive potential of yeast cells"
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