Instytut Nauk Medycznych / Institute of Medical Sciences
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Item Comparison of Invasive and Non-Invasive Blood Pressure Measurements During Mechanical Thrombectomy for Acute Ischemic Stroke Under General Anesthesia – A Pilot Study.(2025-07-15) Wiącek, MarcinIntroduction Intra-procedural hypotension during endovascular therapy (EVT) for acute ischemic stroke (AIS) is linked to poorer outcomes. Although continuous invasive blood pressure (IBP) monitoring could help guide timely clinical decisions, it is not routinely implemented during mechanical thrombectomy (MT) under general anesthesia. Objectives This study aimed to assess the agreement between continuous IBP and intermittent non-invasive blood pressure (NIBP) monitoring during EVT and to evaluate whether IBP monitoring impacts procedural timing. Patients and Methods In this prospective observational study, 30 patients undergoing MT for AIS under general anesthesia were enrolled. Blood pressure was simultaneously recorded using radial arterial lines (IBP) and oscillometric cuffs (NIBP, every 5 minutes). Bland–Altman plots were used to assess agreement. Clinically relevant discrepancies and door-to-groin (DTG) times were compared between patients with planned IBP and those without. Results A total of 481 matched BP readings were analyzed. Mean differences between IBP and NIBP for systolic blood pressure (SBP) and mean arterial pressure (MAP) were small (–0.64 mmHg and –0.99 mmHg, respectively), but agreement limits were wide (SBP: –40.6 to 39.4 mmHg; MAP: –28.5 to 26.5 mmHg). Diastolic pressure showed poor agreement (mean bias –7.64 mmHg). Significant SBP differences (≥20 mmHg) occurred in 41.0% of procedure time, and MAP discrepancies (>15 mmHg) in 29.6%. Median DTG times were similar between groups (41 vs. 38 minutes; p = 0.217). Conclusions Intermittent NIBP monitoring demonstrates limited agreement with continuous IBP, particularly under hypotensive conditions, and may fail to detect meaningful hemodynamic shifts. Importantly, the use of IBP does not appear to delay treatment initiation. These results support further investigation in larger studies.Item Frequency, preferences, and determinants of energy drink consumption among young polish people after the introduction of the ban on sales to minors(MDPI, 2025) Polak-Szczybyło, EwelinaBackground: In Poland, consumption of energy drink among young people has changed significantly following the introduction of a ban on sales to minors. This reg-ulatory measure was intended to address growing concerns about the health effects of high caffeine consumption among teenagers. The aim of the article was to assess the effectiveness of the ban on the sale of energy drinks to minors and to examine the level of knowledge of young people about the harmfulness of consuming these drinks. Methods: The study was conducted in 2024 in Poland after the introduction of a law that prohibited the consumption of energy drinks among minors. The study group consisted of 999 people aged 15-17. Results: 52% of the respondents declared that they consume ED, and 68% reduced their consumption after the introduction of regulations prohibiting sales to minors. This type of drink is used more frequently by men, and age and frequency were also positively correlated. The factors that most often influenced the choice of ED are price, taste, package size, caffeine content, composition, or recommendations from friends. Conclusions: Although a large percentage of minors still drink energy drinks, new regulations have had an impact on limiting the amount of ED consumed.Item Important role of pregnancy planning for pregnancy outcomes in type 1 diabetes(MDPI, 2025-06-01) Juza, Anna; Dąbrowski, MariuszBackground/Objectives: Pregnancy in women with type 1 diabetes (T1D), compared to general pregnant population, is still associated with an increased number of perinatal complications affecting both fetus and mother. The Great Orchestra of Christmas Charity Foundation (GOCCF) program enables use of continuous subcutaneous insulin infusion (CSII) enhanced by hypo-stop function with real-time continuous glucose monitoring (rtCGM) at the stage of procreation or early pregnancy in T1D patients. The aim of this observational study was to analyze association between pregnancy planning and pregnancy outcomes in patients qualified for the GOCCF program. Methods: 98 women with T1D, aged 21-41 years, initiating CSII + rtCGM system at the stage of planning/early pregnancy or later in case of unplanned pregnancy were quali-fied for the study. We analyzed glycemic control, insulin requirements, pregestational BMI, maternal weight gain, occurrence of preterm birth, congenital malformations and birthweight of newborns. Results: Women who planned pregnancy had significantly better glycemic control before and throughout entire pregnancy and significantly higher proportion of them achieved TIR >70% (58.7% vs. 28.9%, P=0.014) and TAR <25% (65.2% vs. 24.4%, P<0.001). Their glucose variability at the end of pregnancy was significantly lower, 29.4±5.5, vs. 31.9±5.1, P=0.030. They also gave birth later, after mean 37.8±0.9 vs. 36.9±1.8 weeks in non-planning group, P=0.039. Preterm birth oc-curred in 5 women (10,4%) who planned pregnancy and in 15 women (30%) with un-planned gestation, P=0.031. Conclusions: Planning pregnancy in T1D is associated with better glycemic control before conception and throughout entire pregnancy, which is translated into better pregnancy outcomes.Item Dataset used in research paper entitled "Plasma Circular-RNA 0005567 as a Potential Marker of Disease Activity in Rheumatoid Arthritis"(MDPI, 2023-12-28) Cieśla, MarekCircular RNAs (circRNAs) are noncoding molecules and are generated through back splicing. The 3′ and 5′ ends of the RNAs are covalently linked and form a loop structure, making it resistant to RNA exonucleases. Thus, circRNAs are biologically stable and may be considered as potential molecular markers of various diseases in tissues and biofluids. CircRNAs may regulate gene expression levels by acting as a microRNA sponge or by interacting with RNA binding proteins. The aim of the study was to find an association between plasma concentration of selected circRNAs and disease activity in patients with RA.Item NGS Bladder cancer(2024-10-08) Cieśla, MarekThe study group comprises 46 patients with urothelial bladder cancers referred for transurethral resection of the tumour. A molecular study on tumour-derived DNA was performed using next-generation sequencing. Somatic mutations were screened in 50 genes involved in cancerogenesis