Instytut Nauk Medycznych / Institute of Medical Sciences
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Item Dataset used in research paper entitled "Plasma Circular-RNA 0005567 as a Potential Marker of Disease Activity in Rheumatoid Arthritis"(MDPI, 2023-12-28) Cieśla, MarekCircular RNAs (circRNAs) are noncoding molecules and are generated through back splicing. The 3′ and 5′ ends of the RNAs are covalently linked and form a loop structure, making it resistant to RNA exonucleases. Thus, circRNAs are biologically stable and may be considered as potential molecular markers of various diseases in tissues and biofluids. CircRNAs may regulate gene expression levels by acting as a microRNA sponge or by interacting with RNA binding proteins. The aim of the study was to find an association between plasma concentration of selected circRNAs and disease activity in patients with RA.Item NGS Bladder cancer(2024-10-08) Cieśla, MarekThe study group comprises 46 patients with urothelial bladder cancers referred for transurethral resection of the tumour. A molecular study on tumour-derived DNA was performed using next-generation sequencing. Somatic mutations were screened in 50 genes involved in cancerogenesis