The Antibacterial Properties of Polish Honey against Streptococcus mutans—A Causative Agent of Dental Caries

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dc.contributorGrabek-Lejko, Dorota
dc.contributor.authorGrabek-Lejko, Dorota
dc.contributor.authorHyrchel, Tomasz
dc.date.accessioned2024-05-16T09:08:37Z
dc.date.available2024-05-16T09:08:37Z
dc.date.issued2024
dc.descriptionExcel file with raw data. Separate sheet for each results published: phenolic content (Folin-Ciocalteau method), antioxidant potential (FRAP method), glucose oxidase activity (GOX), hydrogen peroxide content (H2O2), antibacterial potential of honey (MIC) and influence of catalase and proteinase addition on the antibacterial potential of honey (CAT-PROT), honey influence on biofilm formation (BIOFILM FORMATION) and biofilm eradication (BIOFILM ERADICATION). These raw data were used to prepare results shown in tables and graphs.
dc.description.abstractStreptococcus mutans is considered the main pathogen responsible for dental caries, one of the major infectious diseases, affecting more than 4 billion people worldwide. Honey is a natural product with well-known antibacterial potential against several human pathogens. The aim of the study was to evaluate the antibacterial efficacy of Polish honey against S. mutans and analyze the role of some bioactive substances on its antibacterial action. The antibacterial potential of different honey varieties (goldenrod, buckwheat, honeydew, and lime) was analyzed using a microdilution assay. Manuka and artificial honey were used as controls. The content of GOX, hydrogen peroxide, total polyphenols, and antioxidant potential was assayed in honey. The influence of catalase and proteinase K on antibacterial activity as well as antibiofilm action was also determined. The strongest antibacterial activity was observed for buckwheat, honeydew, and manuka honey, which were also characterized by the highest antioxidant activity and polyphenols content. Catalase treatment decreases the antibacterial activity of honey, while proteinase K treatment influences the antibacterial potential of honey slightly less. Obtained results suggest that honey can be a good natural product against S. mutans, and hydrogen peroxide was identified as a crucial contributor to its antimicrobial action.
dc.description.sponsorshipNational Science Centre (Poland), Miniatura 5, grant no. 2021/05/X/NZ9/00465
dc.identifier.citationGrabek-Lejko, D.; Hyrchel, T. The Antibacterial Properties of Polish Honey against Streptococcus mutans—A Causative Agent of Dental Caries. Antibiotics 2023, 12, 1640.
dc.identifier.doihttps://doi.org/10.3390/antibiotics12111640
dc.identifier.urihttps://rdb.ur.edu.pl/handle/item/42
dc.language.isoen
dc.publisherMDPI
dc.rightsCC0 1.0 Universalen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjecthoney
dc.subjectantibacterial
dc.subjectbiofilm
dc.subjectantioxidants
dc.subjectGOX
dc.subjecthydrogen peroxide
dc.subjectpolyphenols
dc.subjectS.mutans
dc.subjectdental caries
dc.titleThe Antibacterial Properties of Polish Honey against Streptococcus mutans—A Causative Agent of Dental Caries
dc.typeraw dataset
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