Potential utility of microRNAs as biomarkers for ventricular arrhythmias in postinfarction heart failure patients

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dc.contributorWójcik, Mariusz
dc.contributor.authorWójcik, Mariusz
dc.date.accessioned2026-10-21T09:53:29Z
dc.date.issued2026-10-20
dc.descriptionThe file contains one record per patient (n = 48). Patient ID corresponds to the sample number of the sequenced plasma sample and allows linkage with the sequencing data. Variables: demographics (age, sex, BMI); year of ICD implantation, number of leads and length of remote monitoring; history of appropriate and inappropriate ICD therapy (antitachycardia pacing, shock) and time since the last intervention (days); ICD interventions and shocks within 6 months after sampling; comorbidities; echocardiographic parameters (LVEF, left ventricular diastolic and systolic diameters, left atrial diameter); haemoglobin and eGFR; pharmacotherapy (beta-blocker, ACE-I/ARB, ARNI, MRA, SGLT2 inhibitor). Binary variables are coded 0 = no, 1 = yes. Missing values are coded as “n/a” in “Time since last intervention” denotes no prior ICD intervention.
dc.description.abstractThis dataset contains anonymised clinical data of 48 patients after myocardial infarction with an implantable cardioverter-defibrillator (ICD) followed by remote monitoring, enrolled in a single-centre study of circulating plasma microRNA profiles assessed by small RNA sequencing. The study aimed to compare microRNA profiles between patients with prior appropriate ICD therapy for ventricular arrhythmia (n = 25) and patients without ICD intervention (n = 23). Blood samples were collected on 14 March 2026, and arrhythmic events were recorded during 6 months after sampling.en
dc.description.sponsorshipThis work was supported by the National Science Centre, Poland (grant number 2025/09/X/NZ2/00644) to M.W.
dc.identifier.urihttps://rdb.ur.edu.pl/handle/item/109
dc.language.isoen
dc.subjectCirculating microRNA
dc.subjectSmall RNA sequencing
dc.subjectImplantable cardioverter-defibrillator
dc.subjectVentricular arrhythmia
dc.subjectSudden cardiac death
dc.subjectIschaemic cardiomyopathy
dc.titlePotential utility of microRNAs as biomarkers for ventricular arrhythmias in postinfarction heart failure patients
dc.title.alternativeCirculating microRNA profiles in post-myocardial infarction ICD recipients with and without prior ventricular arrhythmias: a small RNA sequencing study in remotely monitored patients
dc.typeprocessed dataset

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