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Dataset used in research paper entitled "Evaluation of anticancer activity of urotropine surface modified iron oxide nanoparticles using a panel of forty breast cancer cell lines "
(Taylor & Francis, 2025-02-28) Adamczyk-Grochala, Jagoda; Wnuk, Maciej; Oklejewicz, Bernadetta; Klimczak, Katarzyna; Błoniarz, Dominika; Deręgowska, Anna; Rzeszutek, Iwona; Stec, Paulina; Ciuraszkiewicz, Agnieszka; Kądziołka-Gaweł, Mariola; Łukowiec, Dariusz; Piotrowski, Piotr; Litwinienko, Grzegorz; Radoń, Adrian; Lewińska, Anna
Urotropine, an antibacterial agent to treat urinary tract bacterial infections, can be also considered as a repurposed drug with formaldehyde-mediated anticancer activity. Recently, we have synthesized urotropine surface modified iron oxide nanoparticles (URO@Fe3O4 NPs) with improved colloidal stability and limited cytotoxicity against human fibroblasts. In the present study, we have investigated URO@Fe3O4 NP-mediated responses in a panel of forty phenotypically different breast cancer cell lines along with three non-cancerous corresponding cell lines. URO@Fe3O4 NPs promoted oxidative stress and FOXO3a-based antioxidant response in breast cancer cells. Elevated levels of GPX4 and decreased levels of ACSL4 in URO@Fe3O4 NP-treated breast cancer cells protected against ferroptotic cell death. On the contrary, URO@Fe3O4 NPs impaired the activity of PERK, a part of unfolded protein response (UPR), especially when the glucose supply was limited, that was accompanied by genetic instability, and apoptotic and/or necrotic cell death in breast cancer cells. In conclusion, this is the first comprehensive analysis of anticancer effects of URO@Fe3O4 NPs against a panel of forty breast cancer cell lines with different receptor status and in glucose replete and deplete conditions. We suggest that presented results might be helpful for designing new nano-based anti-breast cancer strategies.
Changes taking place in the media image of an academic organization. Study on the example of students' opinions.
(2025-03-24) Garwol, Katarzyna
At the intersection of media studies, sociology of education and public relations, the concept of the image of an academic organization is situated. Contemporary the media image of university is the result of interaction with institutional messages conducted often in social media and through various digital platforms. The theory of the university image is a developed research field, however, recent changes in media and educational landscape, due to the Covid-19 epidemic, resulted with a research gap. This paper describes an empirical research conducted by the authors, that is dedicated to uncover changes in the perception of the image of the university and the faculty/college from the student's perspective after long period of hybrid and online studies. The subject was narrowed down to the media image of academic organization created through websites and social media. The state of art part of the paper proves why attention should be paid to the ubiquity of digitization in academic education and the intensifying digitalisation of communication. CAWI research conducted at selected public universities in Poland (University of Warsaw and University of Rzeszów). The collected and recent material allows to identify aspects of university image related to organizational communication.
Dataset used in research paper entitled: Riboflavin overproduction on lignocellulose hydrolysate by the engineered yeast Candida famata
(Oxford Academic, 2024-07-15) Dzanaeva, Ljubov; Wojdyła, Dominik; Fedorovych, Dariya; Ruchała, Justyna; Dmytruk, Kostyantyn; Sibirny, Andriy
Lignocellulose (dry plant biomass) is an abundant cheap inedible residue of agriculture and wood industry with great potential as a feedstock for biotechnological processes. Lignocellulosic substrates can serve as valuable resources in fermentation processes, allowing the production of a wide array of chemicals, fuels, and food additives. The main obstacle for cost-effective conversion of lignocellulosic hydrolysates to target products is poor metabolism of the major pentoses, xylose and L-arabinose, which are the second and third most abundant sugars of lignocellulose after glucose. We study the oversynthesis of riboflavin in the flavinogenic yeast Candida famata and found that all major lignocellulosic sugars, including xylose and L-arabinose, support robust growth and riboflavin synthesis in the available strains of C. famata. To further increase riboflavin production from xylose and lignocellulose hydrolysate, genes XYL1 and XYL2 coding for xylose reductase and xylitol dehydrogenase were overexpressed. The resulting strains exhibited increased riboflavin production in both shake flasks and bioreactors using diluted hydrolysate, reaching 1.5 g L-1.
Research data for the article "The influence of biological preparations on soil parameters and aclonifen dissipation"
(Springer Nature, Scientific Reports, 2025) Szpyrka, Ewa; Praskowicz, Aleksandra; Serwin, Natalia; Książek-Trela, Paulina
Food production requires the protection of agricultural crops against weeds, diseases and pests. An inherent consequence of using chemical plant protection products is the presence of their residues in the environment and the soil, and also in food. The use of effective microorganisms (EMs) that protect plants against pathogens and improve the condition of the soil, may be an alternative to and complement those preparations. The aim of this work was to examine the potential of biological preparations containing Bacillus amyloliquefaciens MBI600, Pseudomonas sp. DSMZ 13134, Yarrowia lipolytica, and their consortia for the revitalization of soil contaminated with aclonifen. Experiments were conducted under controlled laboratory conditions in the horticultural soil. The analyzed parameters included the aclonifen concentrations, and soil parameters of pH, dehydrogenase activity (DHA), and oxidation-reduction potential (ORP). The consortium of Pseudomonas sp. DSMZ 13134 with Y. lipolytica and the consortium of all three examined EMs most effectively influenced the aclonifen dissipation. Their use reduced the herbicide concentration in the soil by 52% and 56%, respectively. These results are significant as aclonifen is a persistent herbicide. The tested biological preparation also contributed to the improvement of soil properties – the increase in ORP and DHA. There is an urgent need to promote the use of EMs in agriculture, to protect the environment and human health from chemical contaminants, and to develop sustainable agriculture.
Tabela atrybutów schowków żołędzi odkrytych w latach 2023 oraz 2024
(2025) Bobiec, Andrzej; Kurek, Przemysław; Wróbel, Aleksandra
The database consist of 323 records of the recovered mili-radiotransmitters dispersed by Jays in acorns from 9 feeding trays representing 6 landscape units. While ca. 80% of the transmitters have been cached inside the stuffed acorns, remaining 20% of transmitters were extracted by birds (or rodents) and dropped or left on trees. Besides the points precise (GNSS) georeferences, the tables contain a number of descriptive attributes of the recovered caches/ miliradiotransmitters, such as the way of an acorn cover, surrounding vegeation, etc.